The Louisville Cardinals aim for their sixth consecutive home victory when they host the Murray State Racers on Thursday. Louisville (1-0) followed a loss to Florida State in its 2022 home opener with five straight triumphs at Cardinal Stadium, with two of the final three coming against ranked opponents. Murray State (1-0) hasn’t defeated the Cardinals since 1984, losing the last six meetings between the in-state rivals.
Kickoff at Cardinal Stadium is set for 7:30 p.m. ET. The Cardinals are 40-point favorites in the latest Louisville vs. Murray State odds, while the over/under for total points scored is 54. Before you make any Murray State vs. Louisville picks, be sure to see the college football predictions from SportsLine expert Micah Roberts.
Roberts has worked in the Las Vegas sportsbook industry for more than 20 years, including a 13-year run as Station Casinos’ book director. Armed with an elaborate network of sources, Roberts has unmatched info in multiple sports. He’s also off to an incredible 7-2 start on against-the-spread college football picks this season, returning almost $500 for $100 bettors. Anyone who has followed him is way up.
Now, Roberts has set his sights on Louisville vs. Murray State and just locked in its picks and CFB predictions. You can head to SportsLine now to see Roberts’ picks. Here are several college football odds and betting lines for Murray State vs. Louisville:
- Louisville vs. Murray State spread: Cardinals -40
- Louisville vs. Murray State over/under: 54 points
- LOU: The Cardinals have held the Racers to 10 points or fewer in five of their last six meetings
- MSU: The Racers went 0-6 on the road last season
- Louisville vs. Murray State picks: See picks at SportsLine
Why Louisville can cover
The Cardinals have won 11 of their last 13 overall matchups against the Racers and nine of the past 11 at home. Nine of those 11 victories were by double digits and all but one were by at least 24 points. Louisville won each of the last two meetings by 45 as it amassed 121 points in those contests.
Despite being outgained 488-474 in their season opener, the Cardinals managed to come away with a 39-34 triumph over Georgia Tech. The club trailed 28-13 at halftime, but Jack Plummer rallied it to victory with a strong second half after struggling early in his team debut. The senior quarterback, who spent his first three years at Purdue with current Louisville coach Jeff Brohm before playing at California-Berkeley last season, completed 10-of-14 pass attempts for 157 yards and two touchdowns over the final two quarters. See who to back at SportsLine.
Why Murray State can cover
The Racers haven’t posted a victory against an FBS opponent since their last win over the Cardinals in 1984. They erupted for five touchdowns in their season-opening 41-10 triumph over Presbyterian, including three on the ground. Sophomore Q’Daryius Jennings led the team in rushing with 50 yards on nine carries and joined redshirt freshman Kylan Galbreath and junior Cortezz Jones with a TD run.
Junior DJ Williams and senior Eric Phoenix each threw for over 100 yards and a score in the victory. Both scoring passes went to Taylor Shields, who hauled in an 18-yarder from Williams just before halftime and a 51-yarder from Phoenix late in the third quarter. The redshirt junior wideout has made a touchdown catch in three consecutive contests dating back to last season. See who to back at SportsLine.
How to make Louisville vs. Murray State picks
Roberts has analyzed this matchup from every angle and he’s leaning Over on the point total. He has also discovered a critical X-factor that has him jumping all over one side of the spread. He’s only sharing what it is, and which side to back, at SportsLine.
Who wins Louisville vs. Murray State, and which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see Louisville vs. Murray State picks, all from the expert who is 7-2 on against-the-spread college football picks this season, and find out.