Notre Dame vs. Clemson odds, spread, line: 2023 college football picks, Week 10 predictions from proven model

A high-profile matchup has lost some of its luster, but No. 15 Notre Dame won’t take it lightly Saturday when they visit Memorial Stadium to face the Clemson Tigers. The Irish (7-2) come into the college football Week 10 matchup in Death Valley on a two-game win streak that includes a victory against then-No. 10 USC. The Tigers (4-4) have lost consecutive games, against Miami and NC State. These teams met in the 2020 ACC Championship Game and the 2018 Cotton Bowl national semifinal, both won convincingly by Clemson. The teams also faced off in South Bend a year ago, and the Irish cruised to a 35-14 victory.

Kickoff is set for noon ET on Saturday in Clemson, S.C. The SportsLine consensus Notre Dame vs. Clemson odds list the Irish as 3-point favorites, and the over/under for total points scored is set at 44.5. Before making any Clemson vs. Notre Dame picks, be sure to check out the college football predictions and betting advice from SportsLine’s proven computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Clemson vs. Notre Dame and just revealed its picks and predictions. You can visit SportsLine to see the model’s CFB picks. Here are several college football odds and trends for Notre Dame vs. Clemson: 

  • Notre Dame vs. Clemson spread: Irish -3
  • Notre Dame vs. Clemson over/under: 44.5 points
  • Notre Dame vs. Clemson money line: Irish -158, Tigers +134
  • ND: Is 5-2 ATS in its past seven road games.
  • CLEM: Is 4-7 ATS at home since last season.
  • Notre Dame vs. Clemson picks: See picks at SportsLine
  • Notre Dame vs. Clemson live stream: fubo (try for free)

Why Notre Dame can cover

The Irish are strong on both sides of the ball, with the offense averaging 428 yards per game (41st in FBS)  and the defense giving up 279 (11th). Their only losses were against Ohio State and Louisville, both currently ranked in the top 15. They also beat a Duke team that was ranked in the top 20. The Irish offense ranks 10th in the nation in yards per play (7.0) and averages 428 yards per game. Quarterback Sam Hartman has 2,126 passing yards and 18 TD passes.  

Running back Audric Estime has rushed for 901 yards and 12 touchdowns, and the Irish average 4.9 yards per carry (29th in FBS). They also score 38 points per game (12th), while Clemson averages 29 (64th). The Notre Dame defense ranks in the nation’s top 11 in total yards (279) and scoring (15.3) and ranks third against the pass (159). The unit also has 18 takeaways, 13 of those interceptions. Safety Xavier Watts has six picks, most in the nation. See which team to pick here.

Why Clemson can cover

The Tigers still have one of the nation’s best defenses, a unit that allows 4.3 yards per play (eighth in FBS) and 3.1 per rush (16th). Opponents are averaging 267 total yards, sixth-fewest in FBS, and 21 points (39th). T.J. Parker leads the team with four sacks, and Xavier Thomas, who has two in six games, is a force when he’s on the field. Linebacker Jeremiah Trotter Jr. has 1.5 sacks, one interception and two forced fumbles, while leading the team with 54 tackles.

Clemson is waiting to see if running back Will Shipley can return from a concussion, but Phil Mafah is also a playmaker. Shipley has 635 total yards and five touchdowns, but Mafah is averaging 6 yards per carry, rushing for 439 and six TDs. Cade Klubnik can manage the game at quarterback and has plenty of weapons. Klubnik has 1,947 passing yards and 13 TDs, and five Tigers have at least 20 receptions. Beaux Collins is averaging 16.2 yards on 30 catches. See which team to pick here.

How to make Notre Dame vs. Clemson picks

SportsLine’s model is leaning Over on the point total, and it also says one side of the spread hits in over 50% of simulations. You can only see the model’s pick at SportsLine

So who wins Clemson vs. Notre Dame, and which side of the spread hits over 50% of the time? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has notched a profit of well over $2,000 on its top-rated college football spread picks, and find out. 

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